Endocrine Abstracts

FGF23 secretion is increased in response to 1,25(OH)2 vitaminD3 (1,25D) and an oral phosphorus (P) load. Patients with chronic kidney disease (CKD) are unable to excrete their dietary P which contributes to an increased secretion of the two major phosphaturic hormones, PTH and FGF23. The increased FGF23 would normally bind to its receptor, klotho-FGFR1 in the renal tubules to increase P clearance and decrease the synthesis of 1,25D. Increased FGF23, P and PTH levels are all as...